Am Rev Respir Dis. 1991 Aug;144(2):452-7.

Matrix-driven pneumocyte differentiation.

Lwebuga-Mukasa JS.

Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.

This commentary presents evidence in support of a hypothesis that adult mammalian alveolar epithelial basement membrane possesses functional and structural domains that determine sites at which type I and type II cells localize. The hypothesis provides a framework for understanding how, after normal repair of the epithelium, a constant ratio of type I and type II cells, and the localization of the cell types is maintained.

Publication Types:

·         Review

·         Review, Tutorial

PMID: 1859074 [PubMed - indexed for MEDLINE]