| Exp Lung Res. 1998 May-Jun;24(3):307-20. |
|
Adhesive characteristics
of type II pneumocyte subpopulations from saline- and silica-treated rats.
Sigurdson SL, Lwebuga-Mukasa JS.
Department of Internal Medicine, SUNY, Buffalo School of Medicine, Buffalo
General Hospital 14203, USA.
Alveolar epithelial cells isolated from silica-treated rat lungs provide a
system for the in vitro study of repair mechanisms. In studies of type II
cell interactions with the extracellular matrix, we observed that type IIB
pneumocytes from silica-treated rats adhered to tissue culture plastic more
readily than do normal type II cells. This paper examines the adhesion characteristics
of IIA and IIB cells and their modulation by divalent cations. We describe
differences in the adhesive behavior of two subpopulations of freshly isolated
type II pneumocytes from saline- and silica-treated rats. The observations
have implications for repair and tissue remodeling in the lung.
PMID: 9635253 [PubMed - indexed for MEDLINE]